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Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves (Englisch) Taschenbuch – 8. April 2014

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Produktbeschreibungen

Pressestimmen

Nathan Myhrvold, Founder and CEO, Intellectual Ventures
"A delightfully opinionated, visionary and controversial romp through synthetic biology, which is one of the most important technologies of our time." Eric Topol, Professor of Genomics, The Scripps Research Institute, and author of "The Creative Destruction of Medicine""Literally reinventing nature could provide solutions to intractable problems with the energy supply, global warming, and human health. In "Regenesis," George Church, a pioneer and pre-eminent force in promoting our ability to "read" DNA sequence, now guides us to the future: "writing" DNA sequence. Teaming up with Ed Regis, Church provides a mind-bending, tour de force account of how this seventh industrial revolution will take hold, and how ultimately the survival of our planet and the human species may rely upon rewriting the code of life. An enthralling journey into the future--with truly profound implications--that should not be missed." Stewart Brand, author of "Whole Earth Discipline""Here you will find the bleeding, screaming, thrilling edges of what is becoming possible with genomic engineering, handsomely framed in the fine-grained fundamentals of molecular biology. It is a combination primer and forecast of what is coming in this 'century of biology' from the perspective of a leading pioneer in the science."
"Kirkus Reviews""[An] authoritative, sometimes awe-inspiring book.... A valuable glimpse of science at the edge." "Publishers Weekly""Exhilarating and scary facts suffuse this book about bioengineering by leading Harvard genetics professor and entrepreneur Church.... [W]hen Church describes current work building microbes with minimal genes, the book takes off - and eventually soars.... [A] stimulating book." Steven Pinker, Harvard College Professor of Psychology, Harvard University, and author of "How the Mind Works "and "The Better Angels of Our Nature""A thoughtful introduction to one of the great frontiers of science, o

"New Scientist"
"Bold and provocative... Church and Regis offer a behind-the-scenes look at synthetic biology, a rapidly emerging field that is reprogramming the genetic code to create organisms and functions not found in nature. "Regenesis" tells of recent advances that may soon yield endless supplies of renewable energy, increased longevity and the return of long-extinct species."
Nathan Myhrvold, Founder and CEO, Intellectual Ventures
"A delightfully opinionated, visionary and controversial romp through synthetic biology, which is one of the most important technologies of our time."
Eric Topol, Professor of Genomics, The Scripps Research Institute, and author of "The Creative Destruction of Medicine"
"Literally reinventing nature could provide solutions to intractable problems with the energy supply, global warming, and human health. In "Regenesis," George Church, a pioneer and pre-eminent force in promoting our ability to "read" DNA sequence, now guides us to the future: "writing" DNA sequence. Teaming up with Ed Regis, Church provides a mind-bending, tour de force account of how this seventh industrial revolution will take hold, and how ultimately the survival of our planet and the human species may rely upon rewriting the code of life. An enthralling journey into the future--with truly profound implications--that should not be missed."
Stewart Brand, author of "Whole Earth Discipline"
"Here you will find the bleeding, screaming, thrilling edges of what is becoming possible with genomic engineering, handsomely framed in the fine-grained fundamentals of molecular biology. It is a combination primer and forecast of what is coming in this 'century of biology' from the perspective of a leading pioneer in the science."
"Kirkus Reviews"
"[An] authoritative, sometimes awe-inspiring book.... A valuable glimpse of science at the edge."
"Publishers Weekly"
"Exhilarating and scary facts suffuse this book about bioengine

"Wall Street Journal"
"A definitive account of the advances and business ventures that define this new science [of synthetic biology].... When history is written centuries from now, it is more likely that writing DNA will be the most enduring innovation [of our age]."
"New Scientist"
"Bold and provocative... Church and Regis offer a behind-the-scenes look at synthetic biology, a rapidly emerging field that is reprogramming the genetic code to create organisms and functions not found in nature. "Regenesis" tells of recent advances that may soon yield endless supplies of renewable energy, increased longevity and the return of long-extinct species."
"Nature"
"The life sciences emerge as the new high-tech in this paean to synthetic biology.... Each step in the genome's evolution serves as a springboard for expositions of how synthetic biology will revolutionize renewable energy, multivirus resistance, and more."
Mike Loukides, "O'Reilly Radar"
"If there's one book that can turn this movement into a full-blown revolution, this is it."
Derek Jacoby, "O'Reilly Radar"
"George Church and Ed Regis pull off an exciting and speculative romp through the field of synthetic biology and where it could take us in the not too distant future.... "Regenesis" provides an accessible and engaging introduction to the revolutionary potentials of synthetic biology and should be of interest to both experts and a general science audience."
"The Scientist"
"[A]n important and surprisingly accessible book, magisterially structured to intertwine the accelerated history of synthetic biology with its precedents in humanity's earlier technological revolutions and in the epochal evolution of life itself. The book packs in a superb short course on life's molecular workings, enabling the reader to grasp how we can actually contemplate resurrecting mammoths and Neanderthals, brewing biofuel from seawater and sunlight, engineering total immunity to vir

"Science News"
"Reading the first book penned by Church, a Harvard biologist and polymath, is like falling down a rabbit hole straight into his fermenting brain. Church's wide-ranging career includes developing novel methods for reading the genetic instruction manual, or genome, of creatures from bacteria to humans. Now he focuses on synthesizing those instructions from scratch.... [A] dizzying survey of how scientists have unearthed the secrets of living organisms and are now using that information to revamp life itself."
Robert T. Gonzalez, io9
"[A] phenomenal read."
"Wall Street Journal"
"A definitive account of the advances and business ventures that define this new science [of synthetic biology].... When history is written centuries from now, it is more likely that writing DNA will be the most enduring innovation [of our age]."
"New Scientist"
"Bold and provocative... Church and Regis offer a behind-the-scenes look at synthetic biology, a rapidly emerging field that is reprogramming the genetic code to create organisms and functions not found in nature. "Regenesis" tells of recent advances that may soon yield endless supplies of renewable energy, increased longevity and the return of long-extinct species."
"Nature"
"The life sciences emerge as the new high-tech in this paean to synthetic biology.... Each step in the genome's evolution serves as a springboard for expositions of how synthetic biology will revolutionize renewable energy, multivirus resistance, and more."
Mike Loukides, "O'Reilly Radar"
"If there's one book that can turn this movement into a full-blown revolution, this is it."
Derek Jacoby, "O'Reilly Radar"
"George Church and Ed Regis pull off an exciting and speculative romp through the field of synthetic biology and where it could take us in the not too distant future.... "Regenesis" provides an accessible and engaging introduction to the revolutionary potentials of synthetic biologys

Werbetext

"Bold and provocative... Regenesis tells of recent advances that may soon yield endless supplies of renewable energy, increased longevity and the return of long-extinct species."-New Scientist

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Von PST VINE-PRODUKTTESTER am 4. Mai 2013
Format: Gebundene Ausgabe Verifizierter Kauf
Ohne Zweifel ist der Author (Mr. Church) ein grosser Fachmann auf seinem Fachgebiet, aber dieses Buch enttäuscht über weite Strecken.
Die Einführung ist unverständlich, es sei denn, man ist Biologe. Sie ist aber auch völlig überflüssig für den Rest des Buches, man muss lediglich glauben, dass die Änderung der Erbanlagen für gewünschte Zwecke eben funktioniert.

Der mittlere Teil des Buches ist wirklich interessant. Es wird beschrieben, was man alles schon kann (z.B. eine AIDS-kranke Person heilen, Benzin mittels irgendwelcher Einzeller aus CO2, Wasser und Sonnenlicht herstellen,.....)

Der Teil, in dem über mögliche Gefahren der neuen Technologie diskutiert wird ist erträglich, aber nicht mehr richtig gut.
Der Schluß ist dann wieder echt übel: Der Author beschreibt seine "Philosophie" - und er ist eben Biologe......

Bis auf den Mittelteil ein sehr enttäuschendes Buch!
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*A full executive summary of this book will be available at newbooksinbrief dot com, on or before Monday, October 29.

DNA was not even discovered until about a century ago, and it's structure remained a mystery until about half a century ago, but since this time our knowledge and understanding of DNA has grown immensely (indeed exponentially). What's more, this understanding has evolved to include not just an understanding of how DNA works, but also how it can be manipulated to help advance our ends. The most glaring example here is the phenomenon of genetically modified food. Though not without controversy initially (and some fringe opposition that lives on to this day), it is fair to say that genetically modified food was one of the major scientific advances of the 20th century. Over and above this, our understanding of DNA appeared to reach its most impressive manifestation with the successful sequencing of the human genome in the year 2000.

For the genetics professor and pioneering genetic engineer George Church, however, genetically modified food and the Human Genome Project are but the tip of the iceberg when it comes to the potential of genomics. Indeed, since the year 2005, the exponential growth rate in our ability to read and write DNA has increased from 1.5-fold per year (a rate that matches Moore's law), to the incredible rate of 10-fold per year (p. 243). This explosion in scientific and technological progress has resulted in dramatic advancements in the areas of biochemicals, biomaterials, biofuels and biomedicine. What's more, advancements in these technologies are but in their incipient stage, and the future of genomics promises to dwarf these initial achievements.
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The author gave a great summary of todays state of art regarding molecular and synthetic biology. Some of his thoughts are pretty impressiv, some are not. But thats what science is all about, right? As an engineer, I have some different opinions (some of those got a new perspective, though. And that is a great thing the author achieved). You might find his style a little bit self concerned if you are german as I am; thats american style writing (you will find at least a bunch of techniques, start-ups, papers and publications where the author is involved and seemingly very willing to describe; on the other hand those are his achievments and to peek into his imperium is worth the effort. I really wonder if he ever sleeps... )

So if you are interested in that field, but had no chance to work in it for a while (in my case i try to cultivate mammalian cells in large scale instead of engineering those cells by myself) that book is really a great chance to get an impression where we stand and what the future might or might not bring...

4 out of 5 stars just to remind everybody, that some modesty wont hurt; If germans would learn to be a little bit more enthusiastic about their achievments we could meet in the middle with our american collegues and might get global projects running more efficiently :)
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Man's ability to manipulate genes to whatever purpose it pleases is indeed a big topic. Replacement of natural designs with liberal criss-crossing of genetical material including potential creations of new species represents an unprecedented step in history of mankind with lots of open ends. Certainly, responsibility of those doing top research in the field of genetics is exponentially growing. Dr. Church certainly belongs to this echelon; first rate introduction into the intricacies of issues involved could and should be expected.
Such mission Dr. Church has missed by a wide margin. Nearly all points he makes are cursory statements ranging form overly detailed descriptions of technicalities to sloppy off hand boulevard sensationalisms. None of the issues is treated sufficiently in - depth to allow general reader to clear the smoke covering the complexities of genetical engineering; let alone to clarify any of the topics. Clearly the collaboration between the scientist and journalist miscarried; the result is a piece of relatively cheap pseudo-science. The reader is left alone to choose between DNA/RNA-hope, promise and scare. Of course some of the offered insights into the state of business of bio-engineering are interesting and valuable, yet their humanitarian context is completely missing. The appeals to the readers to check out for another planet in the future and to save human intelligence for the Universe appear exotic at best. If one day Dr. Church decides to put his mind to the pen in a more thoughtful way we might indeed profit from his unquestionable expertise. As long as he doesn't we better stick with reading the classics in the field such as The logic of life by F. Jacob or The eigth day of creation by H.F. Judson.
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