- Gebundene Ausgabe: 1096 Seiten
- Verlag: Elsevier Ltd, Oxford; Auflage: 8th edition. (29. Dezember 2011)
- Sprache: Englisch
- ISBN-10: 0125468075
- ISBN-13: 978-0123749475
- ASIN: 0123749476
- Größe und/oder Gewicht: 22,4 x 4,3 x 27,7 cm
- Durchschnittliche Kundenbewertung: Schreiben Sie die erste Bewertung
- Amazon Bestseller-Rang: Nr. 57.103 in Fremdsprachige Bücher (Siehe Top 100 in Fremdsprachige Bücher)
- Komplettes Inhaltsverzeichnis ansehen
Basic Neurochemistry: Principles of Molecular, Cellular, and Medical Neurobiology (Englisch) Gebundene Ausgabe – 29. Dezember 2011
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Über den Autor und weitere Mitwirkende
OBITUARY FOR R. WAYNE ALBERS, August 5, 1928 - September 28, 2013 R. Wayne Albers, Ph.D., Scientist Emeritus, Chief of Section on Enzyme Chemistry (retired), Laboratory of Neurochemistry in the NINDS, NIH, Bethesda, MD, is a world-recognized neuroscientist most noted for his research in the field of membrane cation transport and neuronal excitability in the nervous system. Dr. Albers and physiologist R.L. Post performed the principal experiments leading to their now widely-held Albers-Post model for the mechanism of the cation transport enzyme, sodium-potassium-activated ATPase. Dr. Albers was one of the founding co-editors of the comprehensive text, Basic Neurochemistry: Molecular, Cellular and Medical Aspects, first published in 1972, continuing as co-editor for 8 editions, the latest having been published in 2012. After receiving his PhD at Washington University School of Medicine in 1954, Dr. Albers embarked on a distinguished career of research at the NIH, being a founding investigator in the first Laboratory of Neurochemistry. Dr. Albers was one of the first members of the American Society for Neurochemistry at its inception, serving on its Council and its Committees on Publications and Education and on Electronic Publications. He has served as Professor of Biochemistry at George Washington University, Faculty Member of the NIH Foundation for Advanced Education in the Sciences, Associate Editor of the Journal of Neurochemistry and of Experimental Neurology, and on the editorial boards of several journals. Dr. Albers passed away on September 28, 2013. He was 85 years old and is survived by his former wife, Frances Albers, their children Gail Morrell, Belinda Caron and Patricia Steinhoff, 6 grandchildren, and 8 great-grandchildren. He also had a son, the late Jonathan Albers. Dr. Albers was considered a gentleman, an excellent scientific colleague with a keen intellect and friend by all who worked with him. He will be sorely missed, not only by his family, but also by the entire neurochemistry community. George J. Siegel October 1, 2013
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I find this book to be a great review of ever-expanding concepts and clarifications of what we know and once knew.
Great improvement form last edition with on-line link to slides and pictures for teaching and presentations.
I hope the future reviews will continue to expand on clinical-correlates (though this is as the name implies not really a primary medical book) of basic sciences and translational research and applications.
Though it lacks in detail in several areas the bibliographies/reference page at the end of the the chapters were/are helpful in leading to further reading. Ofcourse when one gains more knowledge in individual chapters-like neurochemicals/transmitters the material here does seem very basic. However in keeping in perspective the amout of research and data behind each chapter, one has to realize that a whole book can be written on each chapter in the book. Thus this may not be all encompassing but definitely a great book to have and channel into more (guided) detail from.
That said, I have some concerns with the chapter on addiction. The author introduces the topic by stating that vulnerability to relapse can persist after years of abstinence (true) and that this suggests that long-lasting and perhaps permanent neurobiologic changes underlie addiction. It might, however, suggest what is generally believed by addiction experts - that a specific neurobiologic condition is present prior to the use of addicting substances, and that this condition is what causes the vulnerability in the first place. The text also notes that long-term drug exposure produces changes that contribute to addiction. This has been well demonstrated, but even single uses of substances also produce significant and identifiable changes; such evidence was detailed as early as the 1960s with alcohol. The author confuses tolerance, physiologic dependence, and sensitization, all present in ANY use of addictive substances, with specific findings present in addictive disease.
The chapter on addiction also contains a sidebar referencing the use of opioid receptor antagonists as being useful in alcoholism, something dismissed by most clinicians due to a paucity of evidence demonstrating any such value. The chapter, ultimately, presents an excellent overview of the neuroscience, but may lead to some mistaken beliefs on the part of readers as to the medical issues present. While this causes me some concern with respect to recommending the text, the majority of readers will use the text for its presentation of the basic science and will likely turn elsewhere for interpretation as to the application and interpretation of such material.
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