If you're looking for another "Dune", be warned: This book takes place on Earth, albiet an Earth that is about to go through some huge changes.
Our story opens with the death of the wife and children of brilliant biochemical researcher John O'Neill at the hands of terrorists. O'Neil is driven mad with grief and unleashes a biochemically engineered plague on the world, one that is 100% fatal to women.
While not Herbert's best book, it is still fantastic. Frank paints a horrific picture of governments racing first against each other to be the first to find a cure, and soon realilsing that a cure will only come with cooperation. Each country deals with the plague differently and the sweep of the story stretches around the world and back to the beginning as O'Neil admires his handiwork.
The story is quite action driven for a Herbert book. With most women dying off, the planet soon becomes unrecognizable. Will a cure be found in time? What form will it take? How will humanity survive? Herbert's trademark philosophical ruminations are there, just below the surface for plucking if you're interested. I will say, though, that the irony of thousand-year-old cultures having to re-write themselves overnight in the name of survival wasn't lost on me.
Even more tantalizing is the ending which will leave you wondering what will happen next. Not that there's a cliffhanger, but the world is so different you imagine a sequal would have done very well.
This is a really good book. It may drag a bit in spots and some of the science involved is a bit dated, but it is still very enjoyable. There's something wrong when a book as good as this one written by a author as popular as Herbert is out of print. Surely there must be some publishing company out there willing to cash in on the writings of a man whose works have been brought to the screen twice (soon to be three times, with "Children of Dune"). Anyone?
Until that happens, pick up a copy at a used bookstore. You won't regret it.