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What's Wrong With My Mouse
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Produktbeschreibungen
Pressestimmen
First Edition Reviews:
"The book successfully brings together the field of behavioral neuroscience and the rewards and insights that can be gained using this approach. I would recommend that every behavioral scientist has at least two copies, one for their own use and one that will be on permanent load to their students, post-doctoral students and colleagues in molecular biology." (Trends in Pharmaceutical Sciences)
"the overall impression is of a helpful guide taking the reader step by step through the complexities of animal behavioral research." (Nature Neuroscience)
"succeeds as a useful introduction to the realm of behavioral phenotyping for those interested in creating or using the large and increasing number of promising targeted mutant mice." (Trends in Neurosciences)
"The book successfully brings together the field of behavioral neuroscience and the rewards and insights that can be gained using this approach. I would recommend that every behavioral scientist has at least two copies, one for their own use and one that will be on permanent load to their students, post-doctoral students and colleagues in molecular biology." (Trends in Pharmaceutical Sciences)
"the overall impression is of a helpful guide taking the reader step by step through the complexities of animal behavioral research." (Nature Neuroscience)
"succeeds as a useful introduction to the realm of behavioral phenotyping for those interested in creating or using the large and increasing number of promising targeted mutant mice." (Trends in Neurosciences)
Kurzbeschreibung
Learn how to conduct behavioral tests to phenotype mutant mice
Dr. Jacqueline N. Crawley, author of the first and second editions of What's Wrong With My Mouse?: Behavioral Phenotyping of Transgenic and Knockout Mice, continues to field hundreds of calls and e-mails from molecular geneticists who ask just that: How do I run behavioral assays to find out what's wrong with my mouse? This book answers that question and many more, including what tests are available to discover an aberrant behavioral phenotype?
Turn to What's Wrong With My Mouse? to discover the wealth of mouse behavioral tasks and to get the guidance you need to select the best methods and necessary controls. Chapters are organized by behavioral domain, including measurements of general health, motor functions, sensory abilities, learning and memory, feeding and drinking, reproductive, social, emotional, and reward behaviors in mutant mice. Throughout the chapters, new behavioral tasks and new research discoveries have been added, bringing the second edition up to date with the latest science. In addition, the second edition includes two new chapters:
*
Neurodevelopment and Neurodegeneration discusses mouse behavioral tasks relevant to neurodevelopmental diseases, such as mental retardation and autism, and to neurodegenerative diseases, such as Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis.
*
Putting It All Together recommends strategies for optimizing a battery of behavioral phenotyping tests to address your specific hypotheses about gene functions.
The final chapter, The Next Generation, examines new and emerging technologies.
Throughout the book, the use of behavioral testing equipment is illustrated with photographs, diagrams, and representative data. Examples of behavioral tasks successfully applied to transgenic and knockout mouse models are provided, as well as references to the primary literature and step-by-step methods protocols. These features, along with a comprehensive index, listings of database and vendor Web sites, suggestions for expert behavioral neuroscientist collaborators, and an extensive list of references, make this book a valuable and practical resource for students and researchers.
Dr. Jacqueline N. Crawley, author of the first and second editions of What's Wrong With My Mouse?: Behavioral Phenotyping of Transgenic and Knockout Mice, continues to field hundreds of calls and e-mails from molecular geneticists who ask just that: How do I run behavioral assays to find out what's wrong with my mouse? This book answers that question and many more, including what tests are available to discover an aberrant behavioral phenotype?
Turn to What's Wrong With My Mouse? to discover the wealth of mouse behavioral tasks and to get the guidance you need to select the best methods and necessary controls. Chapters are organized by behavioral domain, including measurements of general health, motor functions, sensory abilities, learning and memory, feeding and drinking, reproductive, social, emotional, and reward behaviors in mutant mice. Throughout the chapters, new behavioral tasks and new research discoveries have been added, bringing the second edition up to date with the latest science. In addition, the second edition includes two new chapters:
*
Neurodevelopment and Neurodegeneration discusses mouse behavioral tasks relevant to neurodevelopmental diseases, such as mental retardation and autism, and to neurodegenerative diseases, such as Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis.
*
Putting It All Together recommends strategies for optimizing a battery of behavioral phenotyping tests to address your specific hypotheses about gene functions.
The final chapter, The Next Generation, examines new and emerging technologies.
Throughout the book, the use of behavioral testing equipment is illustrated with photographs, diagrams, and representative data. Examples of behavioral tasks successfully applied to transgenic and knockout mouse models are provided, as well as references to the primary literature and step-by-step methods protocols. These features, along with a comprehensive index, listings of database and vendor Web sites, suggestions for expert behavioral neuroscientist collaborators, and an extensive list of references, make this book a valuable and practical resource for students and researchers.
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Kundenrezensionen
Die hilfreichsten Kundenrezensionen
Format:Gebundene Ausgabe
It is a much prized addition... and fulfills a heretofore unmet need for a comprehensive sourcebook of mutant mouse literature and procedures. In addition to its reference utility, Dr. Crawley's text can exert a valuable influence on the future of transgenic and knockout mouse research by standardizing behavioral phenotyping methods according to the present state-of-the-art. --Stephen C. Heinrichs, Ph.D., Boston College
Format:Gebundene Ausgabe
Very timely given the increasingly recognized importance of providing behavioral phenotypes of mutant mice. I would recommend the book with enthusiasm. --Eric Nestler, Yale University School of Medicine
Die hilfreichsten Kundenrezensionen auf Amazon.com (beta)
Amazon.com:
6 Rezensionen
11 von 12 Kunden fanden die folgende Rezension hilfreich
Expert Review
17. Mai 2000
Format:Gebundene Ausgabe
"This timely book enumerates and describes practically all tests currently used to evaluate mouse behavior. It is a very valuable resource for both beginning and experienced researchers in this field." --Wim E. Crusio, CNRS
7 von 8 Kunden fanden die folgende Rezension hilfreich
an excellent resource
8. Juni 2000
Format:Gebundene Ausgabe
Very timely given the increasingly recognized importance of providing behavioral phenotypes of mutant mice. I would recommend the book with enthusiasm. --Eric Nestler, Yale University School of Medicine
5 von 7 Kunden fanden die folgende Rezension hilfreich
Review
14. Juni 2000
Format:Gebundene Ausgabe
It is a much prized addition... and fulfills a heretofore unmet need for a comprehensive sourcebook of mutant mouse literature and procedures. In addition to its reference utility, Dr. Crawley's text can exert a valuable influence on the future of transgenic and knockout mouse research by standardizing behavioral phenotyping methods according to the present state-of-the-art. --Stephen C. Heinrichs, Ph.D., Boston College
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