The scope of this book is simply unbelievable. Everything you've ever seen about numbers, plus everything you ever wanted to know, and then numbering systems you never even knew existed. Nothing short of fantastic.
A major expansion of Ifrah's earlier work, From One to Zero, the tone is a bit more scholarly than Lowell Bair's (the original translator's) relaxed style in the 1981 original, which makes you feel like you're having a chat with your professor. I really got the impression that Ifrah wanted a more serious work this time; something that could be consulted by experts. I'm not panning the book for this; it just makes for different reading. Plus, the addition of an index certainly makes the book easier to use for research.
Another nice addition was the increased use of typography for non-European text. While Ifrah's effort in hand-drawing everything in the 1981 version was admirable, it feels a bit strange reading handwritten characters in languages he doesn't know (Chinese, for example). Real fonts (like the ones used for Arabic) were a wise investment.
The section on gematria (using the numerical values of letters for divination, wordplay, etc.) is another reason to pick this book up. It seems that if people try hard enough, they can make just about anything into '666'. ^_^; He also went into detail about how different cultures actually did (and do) arithmetic -- mighty interesting stuff for math students and teachers even today!
In short, this is the world's definitive work on numerals. You simply won't find anything better, anywhere.
Also highly recommended: Number Words and Number Symbols by Karl Menninger, published by Dover Books.