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The Epigenetics Revolution: How Modern Biology is Rewriting our Understanding of Genetics, Disease and Inheritance
 
 

The Epigenetics Revolution: How Modern Biology is Rewriting our Understanding of Genetics, Disease and Inheritance [Kindle Edition]

Nessa Carey
5.0 von 5 Sternen  Alle Rezensionen anzeigen (2 Kundenrezensionen)

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Produktbeschreibungen

Pressestimmen

'A book that would have had Darwin swooning - anyone seriously interested in who we are and how we function should read this book.' -- Guardian '[A] splendidly clear explanation' -- Colin Berry The Oldie 'Fascinating stuff.' -- Bookseller 'Nessa Carey takes us on a lively and up-to-date tour of what's known about epigenetic mechanisms and their implications for ageing and cancer.' -- BBC Focus 'A hugely compelling explanation of the very latest from the frontline of modern biology ... The Epigenetics Revolution traces the thrilling path this discipline has taken over the last twenty years.' -- Waterstones The Daily Mail: http://www.dailymail.co.uk/health/article-2031505/Audrey-Hepburn-Is-key-stopping-obesity-epidemic.html?ito=feeds-newsxml -- The Daily Mail Nessa was well mentioned on HuffPost. No direct mention of the book, but a link in the article to the Daily Mail Hepburn piece: http://www.huffingtonpost.com/stephan-b-tanda/non-communicable-diseases_b_973156.html -- Huffington Post A review from India on the Sakal Times website: http://www.sakaaltimes.com/sakaaltimesbeta/20110912/4661755374037033104.htm -- Sakal Times At the beginning of this century enormous progress had been made in genetics. The Human Genome Project finished sequencing human DNA. It seemed it was only a matter of time until we had all the answers to the secrets of life on this planet. The cutting-edge of biology, however, is telling us that we still don't even know all of the questions. How is it that, despite each cell in your body carrying exactly the same DNA, you don't have teeth growing out of your eyeballs or toenails on your liver? How is it that identical twins share exactly the same DNA and yet can exhibit dramatic differences in the way that they live and grow? It turns out that cells read the genetic code in DNA more like a script to be interpreted than a mould that replicates the same result each time. This is epigenetics and it's the fastest-moving field in biology today. The Epigenetics Revolution traces the thrilling path this discipline has taken over the last twenty years. Biologist Nessa Carey deftly explains such diverse phenomena as how queen bees and ants control their colonies, why tortoiseshell cats are always female, why some plants need a period of cold before they can flower, why we age, develop disease and become addicted to drugs, and much more. Most excitingly, Carey reveals the amazing possibilities for humankind that epigenetics offers for us all - and in the surprisingly near future -- Good Reads 'This is a readable book that applies scientific theory to the everyday world.' -- Bookseller 'Her book combines an easy style with a textbook's thoroughness.' -- Nature 'Full of illustrations and entertaining metaphors.' -- Nature 'Sees DNA as a film script, with plenty of room for interpretation and retakes. Carey's experience of the biotechnology industry shows in her concluding remarks on the pros and cons of our growing understanding of epigenetics for drug discovery, and on understanding the impact of diet and environment on disease.' -- Nature '[Nessa Carey] explains all clearly, while sucking in the uninitiated with intriguing tales of queen bees, tortoiseshell cats, un-identical identical twins and lots more.' -- Australian 'An exhilarating exploration of an exciting new field, and a good gift for a bright biology student looking for a career choice.' -- Kirkus Review

Kurzbeschreibung

At the beginning of this century enormous progress had been made in genetics. The Human Genome Project finished sequencing human DNA. It seemed it was only a matter of time until we had all the answers to the secrets of life on this planet. The cutting-edge of biology, however, is telling us that we still don't even know all of the questions. How is it that, despite each cell in your body carrying exactly the same DNA, you don't have teeth growing out of your eyeballs or toenails on your liver? How is it that identical twins share exactly the same DNA and yet can exhibit dramatic differences in the way that they live and grow? It turns out that cells read the genetic code in DNA more like a script to be interpreted than a mould that replicates the same result each time. This is epigenetics and it's the fastest-moving field in biology today. The Epigenetics Revolution traces the thrilling path this discipline has taken over the last twenty years. Biologist Nessa Carey deftly explains such diverse phenomena as how queen bees and ants control their colonies, why tortoiseshell cats are always female, why some plants need a period of cold before they can flower, why we age, develop disease and become addicted to drugs, and much more. Most excitingly, Carey reveals the amazing possibilities for humankind that epigenetics offers for us all - and in the surprisingly near future.


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5 von 5 Kunden fanden die folgende Rezension hilfreich
5.0 von 5 Sternen Faszinierende neue Erkenntnisse 26. Dezember 2012
Format:Kindle Edition|Von Amazon bestätigter Kauf
Nessa Carey beschreibt in ihrem Buch einen aktuellen Überblick über die "Epigenetik", was man als "persönliche Ausprägungen" des Gen-Codes beschreiben kann. Bei der Gelegenheit erklärt sie auch, weswegen die Vorstellungen und Träume über Genmedizin nicht Realität geworden sind und was für Möglichkeiten sich tatsächlich bieten. Sehr grob gesagt geht es hier um Mechanismen, mit denen ein Gen mehr oder minder stark Wirkung zeigt (einschließlich abschalten), was die Funktionsweise des Körpers natürlich grundlegend beeinflussen kann. Solche Änderungen können kurzfristig sein -- z.B. im Stundenbereich nach Sport -- oder aber lebenslang im Mutterleib angelegt werden.

Das Buch selbst liefert dicht gepackt Informationen in steigender Konzentration, logisch auf den vorherigen Kapiteln aufgebaut. Für den Nicht-Biologen lohnt es sich schon, dann und wann noch nachzublättern, was eigentlich die eine oder andere Zellart noch einmal genau war. Ansonsten aber ist das Buch gut konzipiert, verständlich geschrieben und sehr überzeugend.

Es wird klar, dass in der Biologie tatsächlich eine Revolution stattfindet, aus der ein grundlegend neues Verständnis zu entstehen scheint. Careys Buch ist sicher kein abschließendes und allumfassendes Werk, stattdessen erlaubt es einen frühen Einblick in diese Umwälzungen und was die zukünftige Forschung bringen mag.
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1 von 1 Kunden fanden die folgende Rezension hilfreich
5.0 von 5 Sternen Fundiert und unterhaltsam 15. März 2013
Format:Taschenbuch
Viele ähnliche Bücher sind entweder für den Laien absolut unverständlich, oder aber es wird so stark vereinfacht dass eine ernsthafte Auseinandersetzung mit dem Thema unmöglich wird. Nessa Carey schafft es ein interessantes Buch zu schreiben, ohne dabei an Anspruch zu verlieren. Es mag keine Lektüre für den fortgeschrittenen Abend sein, denn oftmals ist Konzentration gefordert um dem Buch angemessen folgen zu können, doch niemals hatte ich Gefühl, vom Dargestellten überfordert zu sein. Voraussetzungen hierfür sind solide Kenntnisse der Englischen Sprache, sowie Interesse an moderner Biologie.
Wer beides mitbringt wird mit diesem Buch viel Freude haben.
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Amazon.com: 4.6 von 5 Sternen  60 Rezensionen
40 von 41 Kunden fanden die folgende Rezension hilfreich
5.0 von 5 Sternen Great science book! 4. Juni 2012
Von Gavin Scott - Veröffentlicht auf Amazon.com
Format:Gebundene Ausgabe
This is one of those books that introduces an entirely new and fascinating topic. A similar work would be Chaos: Making a New Science which introduced the concepts of chaotic dynamical systems at a time when even many practitioners of the sciences would not have heard of it.

Similarly, this book introduces the discoveries in epigenetics (epi- meaning "on", or a layer on top of classical genetics) and pretty much all of this will be new information unless you have been actively working in the field of cell biology over the past few years.

The book talks about the paradigm shift that is occurring as cell biologists are realizing that this epigenetic information is as complex and important to the correct function of life as the underlying DNA genome, and even allows for Lamarckian inheritance in certain cases where an offspring's own epigenetic information and phenotype can be influenced by that of the parents, meaning that some environmental effects in a parent's life can directly influence future generations.

Also much of the non-protein-coding genome that for many years was considered to be unimportant "junk" is now turning out to be very important as it can be transcribed into functional RNA molecules that perform important functions. The book contains a simple graphic showing that the ratio of the non-protein-coding DNA to that of traditional protein coding genes increases in direct proportion with the complexity of the organism. The fundamental genes and proteins between say a chimpanzee and a human are virtually identical and it now begins to look as though it's that "junk" DNA that makes all the difference.

This is a fascinating look at recent developments in the ever-accelerating biological revolution and I highly recommend it to everyone who yearns to understand how life works.

G.
24 von 25 Kunden fanden die folgende Rezension hilfreich
5.0 von 5 Sternen Could hardly be more fascinating! 2. Januar 2012
Von tiggrie AKA Sarah - Veröffentlicht auf Amazon.com
Format:Kindle Edition
Word of warning - I may gush! I'm no biologist, but Nessa Carey manages to make epigenetics clear and incredibly interesting to me. This is not an easy read, in that it requires one to think and occasionally to do a little mental gymnastics to get one's head around the concepts she introduces, but nevertheless it's the kind of book that can be gulped down in large servings because Carey is skilled at explaining these high-falutin' concepts so well.

The topics range from inherited traits to cloning and back again, and I found even the descriptions of how certain experiments were undertaken were such that they read incredibly well. This is a book that could havebeen dry as dust, but it's not.

I think probably one where the time taken to read the sample is well spent - I'm sure some people just won't find this that interesting - but if you are at all interested in science, biology, DNA, and the mystery of how things are and aren't passed on, then this is a must read. Absorbing, educational, and downright fascinating. Brilliant.
15 von 16 Kunden fanden die folgende Rezension hilfreich
5.0 von 5 Sternen Superb Reading 16. Juni 2012
Von Deborah DePreta - Veröffentlicht auf Amazon.com
Format:Gebundene Ausgabe|Von Amazon bestätigter Kauf
What a refreshingly erudite and informative book! It was in-depth, at times jam packed with information, particularly for a person with no biology background, but the author went to great length to explain in a very understandable manner some of the complexity of epigenetics, genetics and the current state of our knowledge about these subjects. I highly recommend this book for the interested reader.
14 von 16 Kunden fanden die folgende Rezension hilfreich
5.0 von 5 Sternen Simple, but not simplistic 18. Dezember 2012
Von Arnie Berg - Veröffentlicht auf Amazon.com
Format:Gebundene Ausgabe
I am writing as a person with a graduate degree in Bioinformatics with a special interest in epigenetics, and I can confidently say that this is one of the clearest introductory presentations of epigenetics that I have encountered. The book is written at the undergraduate level, but it is not simplistic. It hits all the high points of epigenetics and pulls together the latest in research into this fascinating area of science. Anyone with a rudimentary background in genetics should have no trouble absorbing the concepts articulated in this book.
9 von 10 Kunden fanden die folgende Rezension hilfreich
4.0 von 5 Sternen The Epigenetics Revolution 19. April 2012
Von Roderick Slieker - Veröffentlicht auf Amazon.com
Format:Kindle Edition|Von Amazon bestätigter Kauf
This book gives a nice overview of the recent findings in the exciting field of epigenetics. It is the perfect book for those who want to have a introduction to the broad variety of studies that are currently done. It is however, not a book for those who have no understanding of basic biology.
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Beliebte Markierungen

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&quote;
To see what everyone else has seen but to think what nobody else has thought &quote;
Markiert von 53 Kindle-Nutzern
&quote;
In this model, epigenetics can be defined as the set of modifications to our genetic material that change the ways genes are switched on or off, but which dont alter the genes themselves. &quote;
Markiert von 33 Kindle-Nutzern
&quote;
Whenever two genetically identical individuals are non-identical in some way we can measure, this is called epigenetics. When a change in environment has biological consequences that last long after the event itself has vanished into distant memory, we are seeing an epigenetic effect in action. &quote;
Markiert von 24 Kindle-Nutzern

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