Encyclopedia articles will cover both primary (basic) considerations, as well as advanced topics, the former aimed at newcomers to the field, the latter at the experienced practitioner who may not necessarily be an expert in the particular area. Article references will cover three areas: original or pioneering work in the area; seminal contributions to the area, including examples illustrating a given application, and; useful review articles. This multi-volume work is the first to provide unparalleled and comprehensive coverage of the full range of topics and techniques. It is suitable for new graduate students who are interested but not yet versed in the subject of mass spectrometry. Techniques, methods and applications of mass spectrometry are described in considerable detail; including limitations, current problems, and areas in which the method does not succeed well.