This collection of strips includes quite a number published elsewhere, with nine starring Mr. Natural, including "... Encounters Flakey Foont", "...the Zen Master", "...in Death Valley", "...Visits the City"; in addition to stories such as "Meatball"; "It's Cosmic"; and a series of images from greetings cards. Selections are from "Evo", "Head Comix", "Yarrowstalks", "Zap Comix" etc...This isn't necessarily Fantagraphics fault as overlap with the more comprehensive "R. Crumb's Carload o' Comics" is because THAT collection was published by J.B. Rund of Kitchen Sink Press.
The book also contains an introduction by Crumb eulogizing his late friend Marty Pahls, and photographs of Crumb, wives Dana and Aline, sister Sandra and friend Pahls.
I'd say it's a decent retrospective for anyone wanting an example of the master of the undergrounds.