As most of the essays in the book were written as newspaper op-ed pieces, they occasionally suffer from "current-itis"; i.e. they were designed with the assumption that the reader would have familiarity with the events being discussed. To that end, I would recommend that people who would like to get the most out of this book brush up a bit on their early-'60's history first.
With that caveat, however, I would strongly encourage anyone with an interest in Ayn Rand's writing to read this book. It is a good example of how to put some of the more abstract parts of Objectivist philosophy into real-world practice. Rand's book "The Romantic Manifesto", for example, becomes more clear in the light of her essay on the television show "The Untouchables".
Also, even if one is not especially interested in period current events, there are some essays of broader scope included after the columns. Of particular note are her essay "The Fascist New Frontier" (an invaluable antidote to the floods of Kennedy worship pumped out by the mass media), and her explanation of why atheists can celebrate Christmas. I believe that both long-time Objectivists and people who are new to the philosophy can find something useful in this book. Furthermore, even if you have no interest in Objectivism, the book is still an enlightening look at a pivotal time in American history.