My family used this guide extensively while travelling in northern Italy this past summer. We found it particularly helpful in Bologna, Venice and the Portofino region. Marcella Hazan, the cookbook author, was a major contributor to the Venice section; if you want a great meal off of the beaten path in Venice, she won't lead you wrong.
I've used the NYC City Secrets guide for years so bought this before our trip. Given the large geographic area and many regions that are covered, it isn't surprising that it lacks the comprehensiveness of the NYC and Rome City Secrets guides. Although we didn't use the guide in Florence, I can see why many reviewers found it lacking for that great city. Although smaller than Rome, Florence deserves a City Secrets book of it's own.