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A Primer of Genome Science (Englisch) Taschenbuch – 21. April 2009

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Über den Autor und weitere Mitwirkende

GREG GIBSON is Professor in the School of Integrative Biology at the University of Queensland in Brisbane, Australia, and holds adjunct appointments at North Carolina State University, USA and the Burnham Institute for Medical Research. He earned a Bachelor's Degree in Biology at the University of Sydney, Australia and a Ph.D. in Cell Biology at the University of Basel, Switzerland (with Walter J. Gehring). Dr. Gibson serves on the editorial boards of several leading journals, and is a Fellow of the American Association for the Advancement of Science. His research is in quantitative genetics and genomics, focusing both on the fruitfly, Drosophila melanogaster, and human variability. SPENCER MUSE is Associate Professor in the Department of Statistics, Bioinformatics Research Center at North Carolina State University, USA. He earned a Bachelor's Degree in Statistics and a Ph.D. in Statistics and Genetics, both at NCSU (the latter with Bruce Weir and Trudy Mackay). Dr. Muse was the recipient of a Sloan Foundation Young Investigator Award (1997-2001). His research is in molecular evolution and bioinformatics.


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20 von 20 Kunden fanden die folgende Rezension hilfreich
A very good, updated introduction to genomics 6. Januar 2010
Von Jeremy Leipzig - Veröffentlicht auf
Format: Taschenbuch
This is an upper level genetics textbook and contains chapters on genome projects, genome sequencing, genomic variation, gene expression, proteomics, and systems biology. There are review questions at the end of the chapters - but that should not imply that this is an elementary textbook. I can only comment on the first four chapters.

Chapter 1 has a somewhat prosaic rundown on the overarching goals of genome sequencing as well as the status of various organisms. There is a interesting section on the history of the competing approaches to the human genome project.

Chapter 2 contains one of the best textbook reviews of BAC and WGSS sequencing techniques I've seen anywhere. Chapter 3, which deals with SNPs is very strong. This is an excellent textbook to get if you are confused about the relationship between QTLs, SNPs, and haplotypes. The authors tie it all together without holding back for fear of overgeneralizing. (e.g. "the vast majority of QTL effects are almost certainly due to as yet unidentified SNPs") You can write a technically correct textbook without explaining things like that but it is no better than a doorstop. I was grateful the authors had the common sense to rise above mere formal pedagogy.

Chapter 4 is very microarray-intensive, which is kind of a shame given how quickly microarrays are disappearing from the scene. RNA-seq is mentioned but it needs to be compared with DGE.

The authors are a geneticist and statistical geneticist and so while very knowledgeable sometimes give the impression of being a bit above the fray with regard current bioinformatic analysis strategies. Because there is no discussion of how short read data is actually processed (hint: it's not with BLAST) the presentation of second and third generation sequencing technology seemed a bit token, but impressive given the time constraints of publishing.

There is room for improvement in the way some topics were discussed in an orthogonal manner but not directly mentioned in the glossary. As I mentioned there is a lot of microarray stuff, a paragraph on CNVs, but the two ideas are not connected via the competitive hybridization technique, which is one of the ways microarrays are still relevant. The terms "methylation" or "epigenetics" are not even in the index even though there is a page on ENCODE.

As I bioinformatics programmer I found this a valuable resource for learning more about population genetics.
Genome Science 23. Mai 2014
Von KimL - Veröffentlicht auf
Format: Taschenbuch Verifizierter Kauf
Although this book outlines techniques very well, it is incredibly dry making it hard to read. It is well organized and is great as a reference. However, if you only need this for a class I would rent the book.
1 von 5 Kunden fanden die folgende Rezension hilfreich
Very good Genomics book 7. Februar 2010
Von JJAJ - Veröffentlicht auf
Format: Taschenbuch Verifizierter Kauf
Up to date content, easy to understand the different topics and good placement of subject on the book. Good examples.
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