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Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics [Englisch] [Taschenbuch]

Lauren Pecorino
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26. April 2012
Cells in our body undergo tightly regulated replication to enable growth to occur in a precise, and to ensure that damaged or worn out tissues are replaced. Regulation is mediated via many different mechanisms; it is when these mechanisms fail, and regulation is lost, that cancer can result. Recent advances in molecular cell biology have greatly expanded our understanding of the processes and mechanisms which underpin the regulation of cell replication, and what is happening at the molecular level when these fail. The third edition of The Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers a fresh approach to the study of the molecular basis of cancer, by showing how our understanding of the defective mechanisms which drive cancer is leading to the development of new targeted therapeutic agents. Opening with an overview of the key hallmarks of cancer as a disease state, the book then leads us through the principal processes that become altered in cancer cells, and explains how the failure of these processes can lead to the onset of cancer. Uniquely, within each chapter, students are shown how this molecular knowledge is being applied to develop new targeted therapeutic strategies. Written with the student learner in mind, the book features a variety of learning features to help students engage with, and master, the concepts presented. The emphasis is not on exhaustive coverage of the field, but on acquiring a solid understanding of the essentials of the subject - and an appreciation of how a theoretical understanding can be transformed into therapeutic benefit. The Molecular Biology of Cancer is an invaluable resource for any student wishing to gain an insight into the molecular basis of the disease, and possible solutions for its effective control. Online Resource Centre The Online Resource Centre to accompany The Molecular Biology of Cancer features: For students: * Hyperlinks to primary literature articles featured in the text * News feeds relevant to cancer biology, drawn from a variety of publications For registered adopters of the book: * Figures from the book, available to download * A test bank of questions, with feedback linked to the book, for use in formative or summative assessment

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Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics + The Biology of Cancer + The Emperor of All Maladies
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  • Taschenbuch: 342 Seiten
  • Verlag: Oxford University Press; Auflage: 3rd edition. (26. April 2012)
  • Sprache: Englisch
  • ISBN-10: 019957717X
  • ISBN-13: 978-0199577170
  • Größe und/oder Gewicht: 18,4 x 23,5 cm
  • Durchschnittliche Kundenbewertung: 5.0 von 5 Sternen  Alle Rezensionen anzeigen (1 Kundenrezension)
  • Amazon Bestseller-Rang: Nr. 77.640 in Fremdsprachige Bücher (Siehe Top 100 in Fremdsprachige Bücher)
  • Komplettes Inhaltsverzeichnis ansehen

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Dr. Pecorino has done a fantastic job... The book's engaging writing-style and well thought out structure welcomes anyone with an interest in studying cancer in thorough, interesting detail. Reading this text was a pleasure, benefited me greatly educationally and made me feel like being a real part of the teaching - as though things were being explained to me in a one-on-one tutorial, an experience that most other medical textbooks don't provide! reviewer Reviews of previous edition: Pecorino gets the balance right between cell and molecular biology, focusing on mechanism rather than disease. Importantly the students like the text and can afford to buy the book. Therefore it is a real support to our learning program and actually used by the students. Dr Bernard Mahon, Biology Department/Institute of Immunology, National University of Ireland Review from first edition The author's infectious enthusiasm as a teacher comes across on every page of this beautifully illustrated book. To guide her readers through this increasingly complex field, she introduces some novel features, including "Special interest" boxes, sections labelled, "Pause to think," well-designed chapter highlights and aids to "Memory refreshment." Given the speed of development of this field, the book is remarkably up to date. Sir David Weatherall, Emeritus Regius Professor of Medicine, Oxford University in THES Textbook Guide - February 2006

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Von Theo
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Gute Einführung in die Molekularbiologie des Krebses. Biologisches Studium oder Medizinstudium Voraussetzung, um den Inhalt zu verstehen. Man bekommt einen guten Einblick in die aktuellen Theorien zur Krebsentstehung und Therapieansätze.
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6 von 6 Kunden fanden die folgende Rezension hilfreich
5.0 von 5 Sternen Third Edition is Superb Addition to any Library 6. Dezember 2012
Von Dr. Terrence McGarty - Veröffentlicht auf
Format:Taschenbuch|Verifizierter Kauf
The introductory book by Pecorino is a superb introduction to the molecular issues related to cancer. The book presents a highly readable and enlightening summary of many of the key issues of pathways and cancer. It can be used as a first step in this exciting field.

The style is straightforward and all encompassing. It can be used by any student who is approaching the field for the first time and it can be an update refresher for those who may have been exposed in the past. It is not of the level of Weinberg but it does address all of the salient issues in a level of depth that allows for a ready follow on using the more in depth texts.

I have used the second edition in the past as a guide to writing materials and obtaining a grasp of broad concepts and issues. The third edition is a superb follow on to the last one.

Chapter 2 is a brief summary of DNA and its interaction in carcinogenesis. Chapter 3 is gene expression. I especially liked the discussion on epigenetic regulation which is a simple and direct coverage of this increasingly important area. Section 3.4 discusses epigenetics and cancer which is current and a critical topic.

Chapter 4 is on growth factor signalling. I typically like to look at the process as a complete system, starting with a statement and model of ligands, receptors, cytoplasmic pathways and then transcription. Although this is done in parts the presentation as an integrated whole is important. The kinase cascades are discussed. One of the general weaknesses of many presentations is the discussion of just how do these proteins interact, at binding sites, and then whether or now one should use kinetic models applicable more appropriately to higher concentrations. Perhaps that goes into more depth than would be necessary but I find it useful for students who have the chemistry background to grasp the concepts. The diagrams are useful and provide constructural understanding.

Chapter 5 discusses the cell cycle. The CDKs are the heart of much of this portion of mitotic growth and the author covers them in adequate detail.

Chapter 6 discusses growth inhibition and tumor suppressor genes. The heart of this is the discussion of p53 the classic control gene. I would have liked a more detailed discussion of ubiquitin and also of the MDM proteins but again for the level of the text's audience the introduction is more than adequate.

Chapter 9 on metastasis is simply stated and gives the reader a somewhat detailed overview. My only critique is that it would have been useful to have a bit more detailed discussion of the ECM, extracellular membrane, its structure, elements, and functions, with a separate subsection. The author does refer to it and provides a reasonable first step.

The author blends therapeutics very well across the presentations showing how progress is made. I would have like some discussion of pathway dynamics. There are many books which detail these approaches but perhaps again this is a bit too much. One final nit is that the experimental basis of the results would be useful to have been added, for example by an Appendix.

Overall the book is a superb addition to anyone's library on molecular cancer genomics.
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5.0 von 5 Sternen great textbook for folks with a science or medicine background or interest 6. Januar 2013
Von B. Fleming - Veröffentlicht auf
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Please read Dr. McGarty's excellent review for details about this really well-written textbook. I'm an internist with an interest in cancer and my oncology training is 25 years old at this point. So, I wanted some "real science" connected to some "real medicine" and this text was perfect for that. To be honest, you need to read this with a white board or paper nearby and approach it as a student would. When she says, take a minute to see if you can diagram this pathway, better do it, because otherwise the progressions will lose you. The author has written a second book- Why Millions Survive Cancer that may be a better introduction for non-health care professionals actually. Both books are excellent; if you are an accountant with an interest in cancer, I would start with her second text "...Survive Cancer" and move to this one next. For health care folks with a serious interest, this text is truly wonderful (for all the reasons stated so eloquently in Dr. McGarty's review.
5.0 von 5 Sternen a fine overview 14. Mai 2014
Von s. berger - Veröffentlicht auf
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As an oncologist I found this book to be timely, well-written, and informative. there are many illustrations to accompany the discussions. I had the first edition of this book and enjoyed that; when I saw that a second edition was available I snapped it up. Turned out the academic center at which I worked recommended it as the basic text for their lectures in molecular biology. It is a useful adjunct for students and physicians, though researchers are probably familiar with the material. Highly recommended.
4.0 von 5 Sternen Good overview for advancecd undergraduates and beginning graduate students 6. Januar 2014
Von Rogera Sauterer - Veröffentlicht auf
Format:Taschenbuch|Verifizierter Kauf
Lauren Pecorino overlapped with me as graduate students at SUNY-Stony Brook where she was doing research on molecular aspects of cancer. I was quite pleased that her book was available when I taught a short course on cancer biology for our beginning graduate students. Though not totally without flaws, Pecorino's book fits the bill for a short upper-level undergraduate or beginning graduate course on the cell and molecular mechanisms of cancer.
The strengths of this book is that it is relatively short (250 pages or so), explains basic concepts clearly, requiring only a basic background in cell and molecular biology, includes key references at the end of each chapter, and includes some clinical correlations and discussions of new targeted therapies utilizing the mechanisms described in each chapter. Pecorino's book is divided into clear, self-contained chapters on various mechanisms of cancer, including genetic mutations and loss of DNA repair mechanisms, major tumor supressors such as Rb and P-53 and their roles in regulation of cell division, signaling pathways and defects in them, epigenetic mechanisms and defects, and metastasis mechanisms. Each chapter explains the basic mechanisms and concepts clearly and succinctly, then goes on to show how these mechanisms are involved in cancer, finishing with descriptions of new, targeted therapy approaches that affect these mechanisms.
The main flaws, though minor, of this book is that there needs to be more discussion on epigenetic mechanisms and cancer, since it is such a rapidly-growing field, and placing all the major signaling pathways important in cancer genesis in a single chapter rather than scattering them in several chapters. Aside from these minor issues, I find this book very well-suited for a short course on the cellular and molecular mechanisms of cancer, which should interest advanced students in cell, developmental and molecular biology as well as those aspiring to clinical careers. It is considerably better than many other texts on the market that are intended for the same audiences.
4.0 von 5 Sternen Good book. A bit confusing. 2. Oktober 2013
Von Mary - Veröffentlicht auf
Format:Taschenbuch|Verifizierter Kauf
This was required for my biology of cancer class. Its a nice lightweight book. Although I like its in-depth analysis of cancer pathways and all, its a bit overly confusing. It also is extremely bland. Unless you need to the book for class (which will be a big supplementary aid!!!) or are very interested/knowledgeable in the workings of cancer, I'd recommend trying some lighter reading first. One can easily get lost in this book's explanations.
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