Let me start out by stating that I am taking auto-tutorial biochemistry at my university. The book is essential to the course. We don't have a professor per se, but rather a test center and some online materials. I am so glad this was the book recommended for use. I did not do so well in organic chemistry. I certainly passed, but the concepts did not stick. This book explains the principles of biochemistry extremely clearly. It reinforces these principles over and over. The order is excellent. While most books immediately lay down foundations and work up, this book goes beyond. It lays the foundations, builds a layer, reinforces the existing foundation, builds another layer, and reinforces any cracks or holes that may have popped up in the foundation once more. The illustrations are clear. If you don't get Figure X-1, then Figure X-2 will likely clear things up for you. Each figure is clearly explained. All angles are approached. There are no holes for students to fall through and miss something, doomed to be completely clueless for the rest of the semester. A lot of textbooks have a habit of leaving traps in the forms of missed concepts, ideas that were not thoroughly explained, and when there is a hole in the foundation, the rest of the semester becomes swiss cheese. If you don't understand nucleophilic attack in organic chemistry, you will probably not understand SN1 or SN2 reactions, and if you don't understand resonance structures, you will not understand aromaticity. In this text, there is no swiss cheese. You will learn and understand biochemistry. You will read along and understand. Key terms are bolded. Figures are given in red text and explained in clear captions. Real-life important examples are given to help reinforce material. You don't have to do a hundred unit problems to reach the next level of understanding; they actually are there to reinforce, and it's actually more like ten problems. The text itself is enough to get an understanding of the principles. I recommend the study guide as well. It asks a lot of questions as you go along and can help diagnose where you've gone wrong if you don't understand something, if you somehow get to that point. I also don't understand why people are rating the quality of the binding. It is a textbook. Textbooks are expensive. You can use this heavy beast to smash a car in half if you wanted to, or stop a train that is in peril of running off a track. What is important is that you are going to learn your biochemistry principles whether you are an excellent student (who reads all the extra stuff on sickle-cell anemia and Alzheimers) or a poor student (who will appreciate idiot-proof figures and reinforcements of previous key principles). Marc Loudon and other big textbook writers should take note.
tl;dr: This is a great textbook for people who want to learn what they need to learn about biochemistry, especially in the first try, without much help.