Introduction to Nitrous Oxide / Oxygen Sedation. Pain and Anxiety Management. Comparison of N2O / O2 Sedation to Other Sedation Methods. History and Evolution of Nitrous Oxide / Oxygen Sedation. Multidisciplinary Application of Nitrous Oxide / Oxygen Sedation. Economic Benefits Associated with Nitrous Oxide / Oxygen Administration. Manufacturing and Distribution of Nitrous Oxide and Oxygen. Patient Assessment. Physical Properties and Pharmacokinetics of Nitrous Oxide. Nitrous Oxide Interaction with the Body. Anatomy and Physiology of Respiration. Titration of N2O / O2 Gases. Technique for N2O / O2 Administration. Signs and Symptoms of Nitrous Oxide / Oxygen Sedation. Recovery from N2O / O2 Sedation. Nitrous Oxide Abuse Issues. Potential Biohazards Associated with Chronic Exposure to Health Personnel. Ethical and Legal Concerns Regarding Nitrous Oxide Administration. Future Trends in Nitrous Oxide / Oxygen Sedation. Appendix A: Referencesappendix B: N2O/O2 Percentage Chart. Appendix C: N2O/O2 Percentage Chart for Constant Oxygen Flow Technique. Appendix D: N2O/O2 Sedation Record. Appendix E: Administration of N2O/O2 Sedation