If you have ever had any doubts, "Gut Symmetries" is proof that Wintersen's fiction demands an educated, intelligent reader who is serious about reading. Call me a snob if you will, but I have no sympathy for anyone who thinks this book is too hard to read or doesn't get the story. This isn't a book that a reader can race through, discarding lyric passages and descriptions wily-nily, picking out the events in chronological order, and hurrying to finish.
In many ways the metaphor is the message. If you want basic "plot" handed to you on a platter, then this book will probably not agree with you. This plot is not constructed in the run-of-the-mill, straightforward, linear plot structure that we have come to expect from television, movies, and mainstream fiction. It does not pander to the modern sense of impatience. Instead, the telling of the story relies on three different narrators, and the story is told using a non-linear episodic plot structure. Like Wintersen's other books, notably "Sexing the Cherry," the reader must rely on subtle clues to connect the pieces of the story together.
As for content, I got so involved in the story that I actually yelled at one of the characters when the "plot twist" (mentioned in the prior reviews) arose. (As well as at two other passages, at least.) Ah but again, perhaps with an eye towards metaphor the message changes...
Reading this book takes a little more effort than the average paperback. You've got to engage your mind (and perhaps, at times, your dictionary) to stay on top of it. In my opinion, it's well worth the read--a fine addition to any modern fiction library.