This is a wonderful written book which I have read through in two days, because I couldn't stop reading. To give a complete account of this reading experience is impossible. Here some simple notices which can not substitute for reading the book by yourself.
CROSS DISCIPLINARY
Nowadays where science inherently is driven by the need of more and more specialization it is increasingly difficult to understand what other disciplines are doing. Reading a technical paper from a foreign discipline without a lengthy and intensive preparation of months or even years you have no real chance to understand it. In such a situation it is a great service if a member of some discipline --here physics-- is writing a book which tries to talk about the important ideas of this discipline in a way, which uses a 'common language'. The book "A Different Universe" from Robert B.Laughlin is for me such a book. Sometimes very personal, it gives you a view into the inner structures of physics which is breathtaking and provoking.
LIMITS OF COMMUNICATION
Clearly, reading such a book as a non-physics is dangerous, but it is a probe of interdisciplinary communication. If it wouldn't be any more possible to talk across disciplines, we would have reached the end of any science, the end of modern societies. Nevertheless reading such a book from another discipline one has to be aware of moving on a slippery ground.
REDUCTIONISM and EMERGENCE
The main theme running through nearly all chapters is the estimate of Laughlin, that the idea of reductionism is a misleading concept for physics, and in fact for all sciences. If one takes the view that we encounter in nature different levels of organization it was --and is-- tempting, to 'reduce' a so called 'higher level' of organization to 'elements' and 'laws' of the lower level. Laughlin explains with many examples and nicely arguments that such a view is too simple for nature, that it is misleading, that it is leading astray into false concepts making research blind for the real dynamics --and 'mystics'-- of nature. There are so many phenomena in science, surrounding everybody in his daily life, which are 'strange' and not yet 'explainable' by scientific theories, that the metaphor of the 'frontier' of the early pioneers can be applied to this situation: the frontier of 'wilderness' has not vanished, it is still there, everywhere, we are part of it.
EXPERIMENT versus THEORY
The other recurring topic is Laughlins criticism against 'antitheories', bodies of thought that stop inquiry and thus impede discovery. Because mathematical structures as such have no 'empirical meaning', it is a luckily case if those structures can successfully be related to empirical measurements (like e.g. in the restricted case of Newtons Laws). But because even 'simple' mathematical structures have by logical reasons always and inevitably more 'meaning' than every measurement can support, it is a challenge to device advanced mathematical structures for ever increasing complex structures which keep a minimum of 'falsifiability'. Laughlin argues that in physics --and even more in other disciplines-- we are faced with more and more cases of mathematical structures which have no clear relationship to interesting experiments, thus he feels compelled to underline strongly the importance of good designed experiments as the cornerstones of real science.
TRUE SCIENCE and SOCIETY
Besides false conceptual strategies which can impede science Laughlin points out psychological, sociological as well as political phenomena which work against an open, problem driven experimental science. The struggle of economical and political power is inducing lots of pressures on the scientific institutions and individuals. This leads to nasty phenomena like fraud, hidden information, hindering laws etc.
As impressive his examples are, I am not sure whether he underestimates the fact that these phenomena are not new in history. But because the level of professionalism and the flow of information is constantly evolving globally the consciousness of these things has been raised too. The human mind potential is globally much, much greater than the official resources of education and research are actually willingly to support. Therefore the struggle for resources is there, it is hard, and --naturally-- for all those, who are excluded, this is dissatisfying and annoying.
NEGATIVE COMPLEXITY
I am wondering why Laughlin does not notice the structural fact that the exponential growth of publicly available knowledge and the individually biological limits of information processing give raise to a kind of 'negative complexity' which destroys inevitably any kind of rationality if human culture does not find a new strategy to cope with this. Even noble laureates will inevitably be lost in such a negative complexity because nobody will be there which can understand there wonderful ideas. Compared with such a negative complexity are the social and political barriers for real science toy problems, because these social and political barriers can in principle be repaired, negative complexity can not be repaired, it will turn every knowledge stepwise in pure noise.
READ IT
Finally I can only recommend again to read the book of Laughlin by yourself. My short remarks here are very poor compared to his exciting text.