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Antibiotic Resistance: Understanding and Responding to an Emerging Crisis (FT Press Science) [Kindle Edition]

Karl S. Drlica , David S. Perlin

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Authored by two leading investigators, this book presents a thorough and authoritative overview of this multifaceted field of science. Pathogenic bacteria have been evolving and spreading resistance to diverse classes of antibiotics. As a result, we risk losing our ability to control and treat infectious diseases. Understanding antibiotic resistance, therefore, is becoming increasingly essential for a broad audience of healthcare professionals, biomedical and public health researchers, students, and policymakers. The authors answer questions such as: What is resistance? How does it emerge? How do common human activities contribute to resistance? What can we do about it? How can we strengthen our “first lines of defense” against resistance? Are there better ways to discover new antibiotics? What unique issues are associated with MRSA and viral influenza? In addition to defining and evaluating one of the most important emerging threats to public health, the authors explain what can be done to minimize risks to public health, and to preserve and extend the effectiveness of existing and new antibiotics.


The emergence and spread of antibiotic resistance is a growing medical and public health emergency. Misuse and overuse of antibiotics is putting us at risk of losing our ability to cure infectious diseases. Karl Drlica and David S. Perlin give an authoritative and thorough explanation of all aspects of antibiotic resistance, from the basic science to the strategies that could minimize resistance problems and extend the life spans of existing antibiotic agents. Intended as the definitive book on a major biomedical issue, Antibiotic Resistance will be required reading for investigators and serious students in microbiology, infectious disease, pharmaceutics, and public health; physicians; and students in pharmacy, medicine, and veterinary medicine.


  • Format: Kindle Edition
  • Dateigröße: 3830 KB
  • Seitenzahl der Print-Ausgabe: 288 Seiten
  • Gleichzeitige Verwendung von Geräten: Bis zu 5 Geräte gleichzeitig, je nach vom Verlag festgelegter Grenze
  • Verlag: FT Press; Auflage: 1 (24. November 2010)
  • Verkauf durch: Amazon Media EU S.à r.l.
  • Sprache: Englisch
  • ASIN: B004DI7ISM
  • Text-to-Speech (Vorlesemodus): Aktiviert
  • X-Ray:
  • Word Wise: Nicht aktiviert
  • Amazon Bestseller-Rang: #977.014 Bezahlt in Kindle-Shop (Siehe Top 100 Bezahlt in Kindle-Shop)

  •  Ist der Verkauf dieses Produkts für Sie nicht akzeptabel?

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Die hilfreichsten Kundenrezensionen auf (beta) 4.4 von 5 Sternen  16 Rezensionen
8 von 8 Kunden fanden die folgende Rezension hilfreich
4.0 von 5 Sternen readable for a layman. too fundamental for experts 29. März 2011
Von reviewer - Veröffentlicht auf
Format:Gebundene Ausgabe|Vine Kundenrezension eines kostenfreien Produkts (Was ist das?)
Having finished the book in one sitting, I flipped back to the preface in search of what its targeted audience is. It was "initially drafted to supplement studies of infectious disease" and the authors later "aim to make the principles of antibiotic use and effectiveness available to a large audience: farmers, hospital administrators.....and especially individual users."

The book's content and style of writing serves well for the above targeted audience. The book is suitable for use at a high school or college freshman year level as a supplement. Interesting historical facts and social ramifications interspersed throughout the book. The book is light on the academic or theoretical side of it, probably intentionally so. It touches on biological mechanisms just enough to make a layman understand what they want to tell next, nothing more. Nonetheless, this book is a laudable attempt to educate the public about the subject.
7 von 8 Kunden fanden die folgende Rezension hilfreich
4.0 von 5 Sternen Trying to Outwit Pathogens Isn't Easy 9. Februar 2011
Von Spudman - Veröffentlicht auf
Format:Gebundene Ausgabe|Vine Kundenrezension eines kostenfreien Produkts (Was ist das?)
"...One of the Klebsiella pneumoniae isolates contained 2 integrons and was resistant to 8 antibiotics. Nucleotide sequence analysis of some of the integrons revealed a complex history involving insertion into a transposon and homologous recombination between transposons."

What's it all mean? I'm not sure, and unfortunately too much of the information in this timely, important book entered my brain like figures shrouded in smoke, visible yet not clearly identifiable, requiring the time and effort to blow away the smoke to come face to face with something unrecognizable anyway. Much of my denseness can be blamed on this English major's non-science background , and some may be attributed to the complexity of the subject matter itself.

The authors establish early that antibiotic resistance is an emerging crisis, one that needs to be addressed immediately, correctly, and ubiquitously to avoid future calamity and a regression in health care to the days before antibiotics. Their goal is widespread dissemination of their critical message and the hope that changes will be made by doctors, patients, governments, and the pharmaceutical companies. Drilica and Perlin state that for those with a solid biology background, "Antibiotic Resistance" will be a quick read. For the lay reader like myself, some chapters are tough to navigate though a glossary of terms is included to help one through the rough waters. I hope that later editions will include a more extensive glossary because some terms that baffled me were not listed.

This book is of interest to all but especially to those directly involved with antibiotics like nurses, those in paramedical fields, patients, and even farmers since many more tons of antibiotics are used on animals that on humans.

Chapters dealing mostly with the biology of pathogens, chemistry, and math formulas containing Greek letters are mostly beyond the scope of this Potato Head. Chapter 6 (Movement of resistant genes among pathogens) and Chapter 8 (Surveillance) were slow motion blurs to me. On the other hand, the last few chapters that detail the seriousness of the situation, what's causing it, and what can be done about it are crystal clear.

Even I have long known about the dangers of over prescribing antibiotics, the dangers of feeding so many antibiotics to animals for growth and maintenance, the dangers of self treatment, and the dangers of overusing and misusing disinfectants and antibiotic ingredients in everything from hand soap to keyboard keys. I am happy to see the mention about unnecessary triclosan overkill, that washing hands with the biocide spiked soaps is no more effective that using plain soap and water. In fact, using agents like triclosan is actually counterproductive.

I like the layout, organization, and urgent message of this book. It would be a great handbook for students and a useful refresher for paramedicals . This is not a book that will entertain with anecdotes and narrative. It's meant to inform and educate and performs that task admirably.
3 von 3 Kunden fanden die folgende Rezension hilfreich
5.0 von 5 Sternen Antibiotic Use: Cause and Effect 1. April 2011
Von M. A. Ramos - Veröffentlicht auf
Format:Gebundene Ausgabe|Vine Kundenrezension eines kostenfreien Produkts (Was ist das?)
The authors outline and explain a problem that is not new but is starting to be brought into the public light. This book is written for people who use antibiotics and is written at an introductory yet clear level. The paramedics, farmers, hospital administrators and especially the public at large should read this book. If you do not have a background in basic biology the authors have included two appendix that give the basic background required to understand the rest of the text and I would recommend starting there.

The book is well presented on how the medical and agricultural use of antibiotics and their misuse has lead to pathogens mutating and becoming antibiotic resistance. And at present dosage and actually overuse of antibiotics will lead to a pathogen that will cause a pandemic. When is not discussed but when you read that rate at which the resistance strain mutate and spread it seems that this should be a subject of high priority. Yet pharmaceutical companies have been shutting down their antibiotic research division for it is not cost effective for them to continue.

The book is informative and not an alarmist manifesto. It covers the facts of use and history of antibiotics and present day measures. And proposes how we may be able to stop this path to a super resistant pathogen; a term not used by the authors. Most people know that the effectiveness of any type of drug diminishes with use and in low dosage the pathogens themselves become resistant. In order to rectify this situation will take a change of culture for all involved; farmers, medical professionals and moist important the general public. At present the authors show that all we are doing at present to slow down the spread and creation of antibiotic resistant pathogens is to increase dosage levels. These increased dosages may have more side effects but avoid the spread of the resistant pathogens.

I highly recommend that this book be read by medical practitioner, farmers and anyone who uses antibiotics. This is a very easy and interesting read.
4 von 5 Kunden fanden die folgende Rezension hilfreich
4.0 von 5 Sternen First strike is still deadly 3. Februar 2011
Von haskpts - Veröffentlicht auf
Format:Gebundene Ausgabe|Vine Kundenrezension eines kostenfreien Produkts (Was ist das?)
Antibiotic resistance is the ability of a microorganism to withstand the effects of an antibiotic.
Antibiotic resistance evolves naturally via natural selection through random mutation, but it could also be engineered by applying an evolutionary stress on a population. Antibiotic resistance is a consequence of evolution via natural selection.

Once such a gene is generated, bacteria can then transfer the genetic information in a horizontal fashion (between individuals) by plasmid exchange. "Antibiotic Resistance: Understanding And Responding To An Emerging Crisis" explains the concept of multiresistant organisms (aka; a "Superbug").

Bacteria which have a mutation allowing them to survive antibiotic intervention will live on to reproduce; passing on this resistance to their offspring in the next generation

Drlica & Perlin point out that the patterns of antibiotic usage greatly affect the number of resistant organisms which develop. Overuse of broad-spectrum antibiotics, such as second- and third-generation cephalosporins, greatly hastens the development of methicillin resistance.

Other factors contributing towards resistance include incorrect diagnosis, unnecessary prescriptions, improper use of antibiotics by patients, and the use of antibiotics as livestock food additives for growth promotion.

The book has the classic hallmarks of becoming a desktop reference for the clinician and those interested in new emerging bio-hazardous threats. I found the glossary very helpful and also the "light" and playful arrangement of facts an figures made the book enjoyable NOT another bland, boring "for scientists only". The layout reminded me of the "... For Dummies" and "The Complete Idiot's Guide To..." books. Which is a good thing. Comprehension of materials is the main point. No use having very dry, stuffy and hard to read or follow books ... which end up covered in dust and cobwebs for their unreadability.
4 von 5 Kunden fanden die folgende Rezension hilfreich
4.0 von 5 Sternen A comprehensive book with some organizational problems 15. März 2011
Von EJ - Veröffentlicht auf
Format:Gebundene Ausgabe|Vine Kundenrezension eines kostenfreien Produkts (Was ist das?)
This book was a bit out of the realm of what I usually review in that it is a textbook, which took me a bit by surprise for the Vine program. Regardless, I plowed through the book while reading others over the course of a few weeks and my thoughts are based on the science, organization, and readability for the average reader.

This book has a lot of excellent detail in it regarding the subject matter as you would expect from a textbook, including in-depth discussions of what a pathogen is in the first place, what antibiotics are and how they work, and how antibiotic resistance is acquired and transmitted. To me, the organization of these subjects did not flow all that naturally. In some cases there was a serious lack of transition from one subject to another with very little to tie them together. However, the authors seem to know their stuff and are actively conducting research in the area.

Overall, I'd advise reading this book in small portions. I'm not sure how easy of a read it would be for someone without a biological background, though there is a detailed glossary for some of the more esoteric terminology. It is not for pleasure reading; rather, it is a reference book to be used for attaining a fairly comprehensive overview of antibiotic resistance. By the end of the book, you will have it.
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